Hepatotoxic drug induced hepatotoxicity

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❓ What is the pathogenesis of drug induced hepatotoxicity?

  • Drug-induced hepatotoxicity is generally idiosyncratic in nature. The pathogenesis of DILI remains enigmatic, but involves exposure to the toxic agent, mitochondrial injury, failure of adaptation, and innate and adaptive immune responses.

❓ What otc drug causes hepatotoxicity?

OTC pain relievers:

Acetaminophen. Nonsteroidal anti-inflammatory drugs (NSAIDs) Aspirin, ibuprofen, and naproxen sodium can cause toxic liver disease if you take too much of the drug or take it with alcohol.

Question from categories: drug induced hepatitis ppt drug induced liver disease ppt drug induced liver injury histology drug induced liver injury ppt drug induced liver injury treatment

❓ Hepatotoxic drugs?

Many such drugs have a known clinical signature (phenotype) of liver injury and causality has been further documented by instances of a positive rechallenge [4,5]. Examples are chlorpromazine, halothane, isoniazid and amoxicillin-clavulanate. In early DILI research, halothane and chlorpromazine were commonly reported causes of hepatotoxicity.

❓ Which drug causes severe form of hepatotoxicity?

  • Acetaminophen. Hepatotoxicity from acetaminophen is due to the toxic metabolite NAPQI…
  • Amoxicillin…
  • Amiodarone…
  • Chlorpromazine…
  • Ciprofloxacin…
  • Diclofenac…
  • Erythromycin…
  • Fluconazole.

❓ Hepatotoxic drugs list?

DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug Discov Today 2016, 21 (4): 648-653.

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Top 130079 questions from Hepatotoxic drug induced hepatotoxicity

We’ve collected for you 130079 similar questions from the «Hepatotoxic drug induced hepatotoxicity» category:

Drug induced nightmares?

Drug-induced nightmares. Assessing causality with an event such as a nightmare is difficult because of the high incidence of nightmares in the healthy population. Using qualitative, quantitative, and possible pharmacologic mechanism criteria, it appears that sedative/hypnotics, beta-blockers, and amphetamines are the therap ….

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Drug induced dyspepsia?

Functional dyspepsia is the term used for patients when endoscopy and other diagnostic tests have ruled out organic pathology. The most common drugs that cause dyspepsia include aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs), which can contribute to mucosal damage, ulceration, and bleeding complications.

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Drug induced anorexia?

Mechanisms of drug-induced anorexia Inhibition of dopamine and serotonin reuptake Increase of satiety-inducing hypothalamic neurotransmitters 8 Endogenous digoxin-like factor disruption Abnormal serum leptin levels Taste alternation Drug-induced nausea or vomiting

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Drug induced angioedema?

Angioedema (AE) is the end result of deep dermal, subcutaneous and/or submucosal swelling, and represents a major criterion in the definition of anaphylaxis. Drug-induced AE, like other cutaneous drug reactions, is most frequently elicited by betalactam

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Drug induced abnormalities?

Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.

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Drug induced anemia?

Drug-induced anemia includes many kind of anemias with different mechanisms. Mechanisms of drug-induced anemia are divided into two groups, namely erythrocyte injury in peripheral blood and damage of erythroid progenitor cells or erythroblasts. Hemolytic anemias are included in the former and megaloblastic anemia, ringed sideroblastic anemia and ...

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Drug induced hallucinations?

Hallucinations / chemically induced* Humans Male Promethazine / adverse effects*

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Drug induced dementia?

Medication-induced dementia is a cognitive impairment of language, memory, and comprehension originating from or complicated by prescription or over-the-counter (OTC) medications. With the wide range of possible drugs that could contribute to the condition and the variance of symptoms, it is difficult to gather concrete evidence for the condition.

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Drug induced hyperthermia?

Diagnosis and treatment of drug-induced hyperthermia DIH is a hypermetabolic state caused by medications and other agents that alter neurotransmitter levels. The treatment of DIH syndromes includes supportive care and pharmacotherapy as appropriate.

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Drug induced hypnosis?

Requires a glass of water. Maybe it will contain a drug that leaves you suggestible... - Intended effect: Left suggestible through feeling drugged. • Downloa...

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Drug induced epilepsy?

Drug-induced seizures are a commonly encountered problem for physicians. In this article, drugs that cause seizures are discussed with regards to the incidence of seizures, associated clinical factors, risk factors, and special treatment considerations. This information should help physicians determ …

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Drug induced homicide?

A person commits drug-induced homicide when he or she unlawfully delivers a controlled substance to another, and any person’s death is caused by the injection, inhalation, absorption, or ingestion of any amount of that controlled substance. Learn more… Dealing Anguish

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Drug induced delirium?

Drugs can cause any of the three types of delirium: hyperactive, hypoactive, and mixed delirium. Both hyperactive and mixed delirium are commonly seen in cholinergic toxicity, alcohol intoxication, certain illicit drug (stimulant) intoxication, serotonin syndrome, alcohol and benzodiazepine withdrawal.

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Drug induced hives?

The most common type of drug reaction is hives, also known as urticaria. They are raised, swollen, red or flesh-colored bumps or welts that appear on the skin. They can take on many shapes and can be very itchy. They usually develop in groups and may cover large areas of skin.

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Drug induced esophagitis?

Drug or pill-induced esophagitis is esophageal mucosal injury caused by the medications and usually refers to a direct toxic effect on esophageal mucosa by the culprit medication. Common symptoms include retrosternal pain, dysphagia, or odynophagia.

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Drug induced fever?

Drug-induced fever is most commonly the result of a hypersensitivity reaction and its characteristics resemble those of an allergic reaction. The fever most commonly occurs after 7 to 10 days of drug administration, persists as long as the drug is continued, disappears soon after stopping the drug, and will rapidly reappear if the drug is restarted.

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Drug induced parkinsonism?

Drug-induced parkinsonism (DIP) is the second-most-common etiology of parkinsonism in the elderly after Parkinson's disease (PD). Many patients with DIP may be misdiagnosed with PD because the clinical features of these two conditions are indistinguishable.

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Drug induced neutropenia?

Drug-induced neutropenia is a potentially serious and life-threatening adverse event that may occur secondary to therapy with a variety of agents. Cytotoxic chemotherapy can cause a predictable and dose-related decrease in neutrophil count.

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Drug induced schizophrenia?

Other drug-induced schizophrenia can be triggered by high doses of stimulants, such as cocaine, amphetamines, and methamphetamine. Not as well known is that some prescription medications can also cause signs of psychosis. These include: Allergy drugs; Anticonvulsants; Corticosteroids; Muscle relaxants; Heart medications; Analgesics; Chemo drugs

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Drug induced migraine?

Medication overuse headaches or rebound headaches are caused by regular, long-term use of medication to treat headaches, such as migraines. Pain relievers offer relief for occasional headaches. But if you take them more than a couple of days a week, they may trigger medication overuse headaches.

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Drug induced pancreatitis?

Class II medications (medications implicated in more than 10 cases of acute pancreatitis): rifampin, lamivudine, octreotide, carbamazepine, acetaminophen, phenformin, interferon alfa-2b, enalapril, hydrochlorothiazide, cisplatin, erythromycin, and cyclopenthiazide. Class III medications (all medications reported to be associated with pancreatitis). Of the top 100 most frequently prescribed medications in the United States, 44 have been implicated in AP, 14 of them fall into either Class I or ...

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Drug induced narcolepsy?

There is a sleeping medication that was recently approved, the function of which is (theorized to be) inducing narcolepsy for a controlled period of time. It does this by blocking Orexin (hypocretin) which is a neurotransmitter believed to promote wakefulness.

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Drug induced paranoia?

Substances that can cause paranoia during intoxication or withdrawal include: Cocaine Methamphetamine Other Amphetamines LSD Bath Salts Hallucinogens Marijuana Alcohol

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Drug induced thrombocytopenia?

Drug-induced thrombocytopenia (DIT) is a relatively common clinical disorder. It is imperative to provide rapid identification and removal of the offending agent before clinically significant bleeding or, in the case of heparin, thrombosis occurs.

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Drug induced toxicity?

Drug-induced nephrotoxicity. Acute kidney injury is a very common diagnosis, present in up to 60% of critical patients, and its third main cause is drug toxicity. Nephrotoxicity can be defined as any renal injury caused directly or indirectly by medications, with acute renal failure, tubulopathies, and glomerulopathies as commo ….

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Drug induced pancytopenia?

Medications that can affect bone marrow function include chloramphenicol, chemotherapy drugs, thiazide diuretics, anti-epileptic drugs, colchicine, azathioprine, and non-steroidal anti-inflammatory drugs (NSAIDs). The list here covers just some of the potential disease-related pancytopenia causes.

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Drug induced thyrotoxicosis?

Background: Drug-induced thyrotoxicosis is not uncommon. It may worsen life-threatening arrhythmias and may be refractory to medical treatment. Near-total thyroidectomy presents a valid alternative to medical therapy and should be considered early in the management of the disease.

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Drug induced tremor?

Drug-induced tremor is a simple nervous system and muscle response to certain medicines. Drugs that can cause tremor include the following: Cancer medicines such as thalidomide and cytarabine; Seizure medicines such as valproic acid (Depakote) and sodium valproate (Depakene) Asthma medicines such as theophylline and albuterol

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Drug induced vasculitis?

Drug-induced vasculitis is an inflammation of blood vessels caused by the use of various pharmaceutical agents. Vasculitis causes changes in the walls of blood vessels, including thickening, weakening, narrowing and scarring. Inflammation can be short-term (acute) or long-term (chronic) and can be so severe that the tissues and organs supplied by the affected vessels do not get enough blood.

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Drug induced vomiting?

Nausea and vomiting, common side effects of drugs, usually occur early in the course of pharmacologic therapy. Often, the symptoms will disappear with continued use. In some instances, concurrent administration of antiemetics may be needed to prevent dehydration and electrolyte imbalances.

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Drug induced sle?

Drug-induced lupus erythematosus is an autoimmune disorder caused by chronic use of certain drugs. These drugs cause an autoimmune response (the body attacks its own cells) producing symptoms similar to those of systemic lupus erythematosus (SLE).

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Drug induced ileus?

Drug-induced ileus is often seen with anticholinergic drugs, opiates, and calcium antagonists. 1, 2, 3 In its mild form, it can cause constipation that resolves with drug cessation. In more severe cases, adynamic ileus can develop with fecal loading that may persist for longer periods and require intervention to relieve it.

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Drug induced rash?

Drug-induced rash is the most commonly reported drug reaction and occurs in a dizzying array of presentations. Changes in lean and fat body tissue, gastrointestinal acid and mucosal permeability, cardiac output, and renal and hepatic metabolism can affect drug absorption, distribution, metabolism, and elimination.

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Thrombocytopenia - drug induced?

DefinitionThrombocytopenia is any disorder in which there are not enough platelets. Platelets are cells in the blood that help the blood clot. A low platelet count makes bleeding more likely.When drugs or medications are the causes of a low platelet count, it is called drug-induced thrombocytopenia.See also: ThrombocytopeniaAlternative NamesDrug-induced thrombocytopeniaCauses, incidence, and risk factorsDrug-induced thrombocytopenia occurs when certain drugs or medications destroy platelets (the cells that help blood clot) or interfere with the body's ability to make enough of them.There are two types of drug-induced thrombocytopenia:

  • Immune
  • Nonimmune
If a drug causes your body to produce antibodies, which seek and destroy your platelets, the condition is called drug-induced immune thrombocytopenia. Heparin, a blood thinner, is probably the most common cause of drug-induced immune thrombocytopenia.If a medicine prevents your bone marrow from making enough platelets, the condition is called drug-induced nonimmunethrombocytopenia. Chemotherapy drugs and a seizure medication called valproic acid may lead to this problem.Other drugs that cause drug-induced thrombocytopenia include:
  • Diabetes drugs taken by mouth
  • Nonsteroidal anti-inflammatory drugs (NSAIDs)
  • Penicillin
  • Quinidine
  • Quinine
  • Ranitidine
  • Some drugs used to treat arthritis conditions
  • Sulfonamides
  • Water pills (diuretics)
SymptomsDecreased platelets may cause:
  • Bleeding when you brush your teeth
  • Easy bruising
  • Pinpoint red spots on the skin (petechiae)
  • Other abnormal bleeding
Signs and testsSee: ThrombocytopeniaTreatmentThe first step in treating this type of low platelet count is to stop using the drug that may be causing the problem.For people who have life-threatening bleeding, treatments may include:
  • Immunoglobulin therapy (IVIG) given through a vein
  • Plasma exchange (plasmapheresis)
  • Platelet transfusions
ComplicationsBleeding can be life threatening if it occurs in the brain or other organs.A pregnant woman who has antibodies to platelets may pass the antibodies to the baby in the womb.Calling your health care providerCall your healthcare provider if you have unexplained bleeding or bruising.ReferencesVisentin GP, Liu CY. Drug-induced thrombocytopenia. Hematol Oncol Clin North Am. 2007;21:685-696.Warkentin TE. Thrombocytopenia due to platelet destruction and hypersplenism. In: Hoffman R, Benz Jr. EJ, Shattil SJ, Furie B, Silberstein LE, eds. Hematology: Basic Principles and Practice. 5th ed. Philadelphia, Pa: Elsevier Churchill Livingstone;2008:chap 140.

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Drug induced tinnitus?

Specific drugs and tinnitus Aspirin. Aspirin in large doses has long been recognised as being able to cause tinnitus and indeed researchers use this... Quinine. Quinine and some of the other anti-malarial drugs can occasionally cause damage to the ear when given in high... Aminoglycoside ...

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Drug induced coagulopathy?

Neuroleptic drug-induced coagulopathy: mechanism of reaction and duration of effect. Zengotita HE, Holt RJ. Patients (N = 32) with documented phenothiazine-induced reductions in platelet levels were evaluated after drug substitution with haloperidol; 28 (88%) patients had normal platelet levels after 1 year of treatment with haloperidol.

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Drug-induced diarrhea?

DefinitionDrug-induced diarrhea is loose, watery stools caused by certain medications.See also: DiarrheaAlternative NamesDiarrhea associated with medicationsCauses, incidence, and risk factorsNearly all medications may cause diarrhea as a side effect. Some medications, however, are more prone to cause diarrhea than others. For example:

  • Laxatives can and are meant to produce diarrhea by drawing water into the gut or increasing the muscle contractions of the intestine. However, taking too much of a laxative, or taking a laxative without being aware of it can cause diarrhea that is a problem.
  • Antibiotics can produce diarrhea by destroying the bacteria of the gut. In some cases, antibiotics can allow a type of bacteria called Clostridium difficile to grow in excess. This can lead to infection and produce a severe, watery form of diarrhea called pseudomembranous colitis.
  • Other drugs may be directly toxic to the digestive tract. Chemotherapy medicines for cancer, or medications that suppress the immune system (such as mycophenolate) are a common cause of diarrhea.
  • Some herbal teas contain senna or other "natural" laxatives that can cause diarrhea.
PreventionTo prevent diarrhea related to antibiotic use, talk to your doctor about taking supplements containing beneficial bacteria (probiotics). Continue taking these supplements for a few days after you finish taking the course of antibiotics.ReferencesSemrad CE, Powell DW. Approach to the patient with diarrhea and malabsorption. In: Goldman L, Ausiello D, eds.Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier;2007:chap 143.

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Drug induced menopause?

Chemical menopause is a term used to describe a temporary (and reversible) menopausal state created with the use of a medication called Gonadotropin Releasing Hormone Analogues (GnRHa) - a type of drug which acts on the pituitary gland in the brain to suppress ovulation and production of ovarian hormones.

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Drug induced itp?

If a medicine causes your body to produce antibodies, which seek and destroy your platelets, the condition is called drug-induced immune thrombocytopenia. Heparin, a blood thinner, is the most common cause of drug-induced immune thrombocytopenia.

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What are hepatotoxic drugs?

Drugs or toxins that have a pharmacological (type A) hepatotoxicity are those that have predictable dose-response curves (higher concentrations cause more liver damage) and well characterized mechanisms of toxicity, such as directly damaging liver tissue or blocking a metabolic process.

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List of hepatotoxic drugs?

DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug Discov Today 2016, 21 (4): 648-653.

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What are hepatotoxic medications?

Hepatotoxic medications are medications considered to be potentially toxic to the liver.

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Which antibiotics are hepatotoxic?

Hepatotoxicity is clearly linked to the clavulanic acid moiety, with a 5- to 9-fold increase for the ...

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Why are antibiotics hepatotoxicity?

Hepatotoxicity Due to Antibiotics. Antimicrobial drugs are important causative agents in idiosyncratic drug-induced liver injury (DILI). As with idiosyncratic DILI in general, antibiotic-induced liver injury is rare but difficult to diagnose and almost impossible to predict. Diagnosis requires awareness of possible causal agents, vigilance in ...

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Which drugs cause hepatotoxicity?

Both hepatocellular and cholestatic injury has been described due to azathioprine [8,9]. Despite the common problem of hepatotoxicity with azathioprine, there is a lack of studies with a significant number of well-characterized patients with this type of liver injury. Table 1.

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Drug induced rash pictures?

A drug rash, sometimes called a drug eruption, is a reaction your skin can have to certain drugs. Almost any drug can cause a rash. But antibiotics (especially penicillins and sulfa drugs), NSAIDs ...

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Drug induced esophagitis symptoms?

Drug or pill-induced esophagitis is esophageal mucosal injury caused by the medications and usually refers to a direct toxic effect on esophageal mucosa by the culprit medication. Common symptoms include retrosternal pain, dysphagia, or odynophagia. It was first reported in 1970 by Pemberton when a …

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Drug induced thrombocytopenia list?

Hundreds of drugs have been implicated in its pathogenesis, among those, drugs most often associated with DITP are: heparin, cinchona alkaloid derivatives (quinine and quinidine), penicillin, sulfonamides, non-steroidal anti-inflammatory drugs (NSAIDs), anticonvulsants, antirheumatic and oral antidiabetic drugs, gold salts, diuretics, rifampicin and ranitidine [23–27]; several other drugs are occasionally described in case reports of thrombocytopenia [28;29].

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Drug induced thrombocytopenia treatment?

Thus, the primary treatment for drug-induced thrombocytopenia is to discontinue the suspected causative agent. Patients experiencing life-threatening bleeding may benefit from intravenous immunoglobulin (IVIG) therapy, plasmapheresis, or platelet transfusions [9;10]. Corticosteroids seem inefficient in the treatment of DIT .

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Acute drug induced cholestasis?

Acute, drug-induced hepatocellular cholestasis (either pure or cholestatic hepatitis) is a common manifestation of drug-induced hepatic injury. The drugs most frequently responsible are hormonal steroids and psychopharmacological agents (in particular phenothiazines and some antidepressants). Choles …

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